In a mixing bowl, combine the ground beef, salt, black pepper, garlic powder, and onion powder. Mix gently until just combined, being careful not to overwork the meat.

Divide the mixture into two equal portions and shape them into burger patties, slightly larger than the size of your lettuce leaves to account for shrinkage during cooking.

Heat olive oil in a skillet or grill pan over medium-high heat. Once hot, cook the patties for 3-4 minutes per side, or until they reach your desired level of doneness.

While the burgers cook, prepare the toppings by slicing the avocado, tomato, and red onion, and washing and patting the lettuce leaves dry.

Once the burgers are cooked, remove them from the heat and let them rest for 2-3 minutes.

To assemble, place a large lettuce leaf on a plate. Add one burger patty on top, followed by slices of avocado, tomato, red onion, and any optional condiments such as Dijon mustard or mayonnaise.

Wrap the lettuce leaf around the burger and toppings, folding it tightly to create a secure wrap. Repeat the process for the second burger.

Serve immediately and enjoy your delicious lettuce-wrapped burger with avocado!